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How Clorazepate Works

Clorazepate enhances the activity of gamma-aminobutyric acid (GABA), the main inhibitory neurotransmitter in the brain. By increasing GABA’s calming effects, clorazepate helps:

Reduce anxiety and nervous tension

Suppress abnormal electrical activity in the brain

Produce sedative and muscle-relaxant effects

Because it is converted into a long-acting metabolite, clorazepate has a prolonged duration of action compared to some other benzodiazepines.

Medical Uses

Clorazepate is commonly prescribed for:

Anxiety disorders

Adjunctive treatment of partial seizures

Alcohol withdrawal symptoms

Short-term relief of severe stress or agitation

It is often used as part of a broader treatment plan that may include psychotherapy or other medications.

Dosage and Administration

Clorazepate is available in tablet and capsule forms for oral use. Dosage varies based on the condition being treated, patient age, and overall health. Treatment typically begins with a low dose, which may be adjusted gradually to achieve the desired effect.

Patients should take clorazepate exactly as prescribed and should not discontinue it suddenly without medical supervision.

Short-Term Side Effects

Common side effects may include:

Drowsiness or sedation

Dizziness

Fatigue

Confusion, especially in older adults

Impaired coordination

These effects may interfere with activities such as driving or operating machinery.

Long-Term Use and Risks

Long-term or improper use of clorazepate can lead to:

Tolerance, requiring higher doses over time

Physical and psychological dependence

Withdrawal symptoms if stopped abruptly

Cognitive impairment or memory problems

Withdrawal symptoms may include anxiety, tremors, insomnia, irritability, and, in severe cases, seizures.