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How Clobazam Works

Clobazam acts on the central nervous system by enhancing the effect of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter. By increasing GABA activity, clobazam:

Reduces excessive electrical activity in the brain

Helps control seizures

Produces calming and muscle-relaxant effects

Its anticonvulsant properties make it especially useful in seizure disorders.

Medical Uses

Clobazam is commonly prescribed for:

Lennox–Gastaut syndrome (LGS) in adults and children

Adjunctive treatment of epilepsy

In some regions, short-term treatment of anxiety disorders

It is usually used in combination with other antiepileptic medications rather than as a first-line therapy.

Dosage and Administration

Clobazam is available in tablets, oral suspension, and film-coated formulations. Dosage depends on factors such as age, weight, seizure type, and response to treatment. Treatment typically starts with a low dose and is gradually increased to minimize side effects.

Patients should take clobazam exactly as prescribed and avoid sudden discontinuation.

Short-Term Side Effects

Common side effects may include:

Drowsiness or sedation

Fatigue

Dizziness

Poor coordination

Drooling (more common in children)

Behavioral changes, such as irritability

Most side effects are dose-related and may improve over time.

Long-Term Risks and Dependence

As a benzodiazepine, clobazam carries a risk of:

Tolerance, reducing effectiveness over time

Physical dependence

Withdrawal symptoms if stopped abruptly

Withdrawal symptoms can include anxiety, insomnia, tremors, and seizures, especially in patients with epilepsy. Gradual dose tapering under medical supervision is essential.

Drug Interactions and Precautions

Clobazam may interact with:

Other benzodiazepines

Opioids

Alcohol

Certain antiepileptic drugs

These interactions can increase sedation, respiratory depression, and overdose risk. Special caution is needed for elderly patients and those with liver or respiratory conditions.